Alkylation of α, β-Unsaturated Cyclic Ketones using Crown Ether as a Catalyst
نویسندگان
چکیده
منابع مشابه
Asymmetric Organocatalytic Reactions of α, β-Unsaturated Cyclic Ketones
The 1,4-conjugate addition of nucleophiles to α,β-unsaturated carbonyl compounds represents one fundamental bond-forming reaction in organic synthesis. The development of effective organocatalysts for the enantioselective conjugate addition of malonate, nitroalkane and other carbon and heteroatom nucleophiles to cycloenones constitutes an important research field and has been explored in recent...
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The Brønsted acid ionic liquid [PyN(CH2)4SO3H][p-CH3PhSO3] has been reported as an efficient catalyst for the Michael addition reaction of indoles to α,βunsaturated ketones. Satisfactory results were obtained, with excellent yields and a simple experimental procedure. The catalyst could be recycled and reused up to three times without any noticeable decrease in the catalytic activity.
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A general and simple procedure to access chiral β'-amino-α,β-enones, in seven steps, from an α,β unsaturated ester has been described. The use of a Horner-Wadsworth-Emmons reaction as a key step for generating the β'-amino-α,β-enones, permits access to a range of substrates under mild conditions and in moderate to high yield.
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ژورنال
عنوان ژورنال: Journal of Japan Oil Chemists' Society
سال: 1978
ISSN: 1884-2003
DOI: 10.5650/jos1956.27.539